NTU

莊曜宇 Eric Y. Chuang
合聘
類別 流行病學與預防醫學研究所
職稱 教授
姓名 莊曜宇 Eric Y. Chuang
電子郵件 chuangey@cc.ee.ntu.edu.tw
聯絡電話 02-33663660
研究專長 生物晶片、生物資訊、癌症生物
最高學歷 美國哈佛大學博士
年度 論文名稱
2012 Kuo, W.H., Y.Y. Chang, L.C. Lai, M.H. Tsai, C.K. Hsiao, K.J. Chang, and E.Y. Chuang, Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas, PLoS One, 7
2012 Lu, T.P., C.Y. Lee, M.H. Tsai, Y.C. Chiu, C.K. Hsiao, L.C. Lai, and E.Y. Chuang, miRSystem: an integrated system for characterizing enriched functions and pathways of microRNA targets, PLoS ONE, 7
2012 Liu, C.C., Y.H. Wang, E.Y. Chuang, M.H. Tsai, Y.H. Chuang, C.L. Lin, C.J. Liu, B.Y. Hsiao, S.M. Lin, L.Y. Liu, and M.W. Yu, Identification of a liver cirrhosis signature in plasma for predicting hepatocellular carcinoma risk in a population-based cohort of hepatitis B carriers, MOLECULAR CARCINOGENESIS, 10.10
2012 Lin, S.Y., S.C. Hsieh, Y.C. Lin, C.N. Lee, M.H. Tsai, L.C. Lai, E.Y. Chuang, P.C. Chen, C.C. Hung, L.Y. Chen, W.S. Hsieh, D.M. Niu, Y.N. Su, and H.N. Ho, A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity, Genes Immun, 13, pp214-220
2011 LH Chen, WH Kuo, MH Tsai, PC Chen, CK Hsiao, EY Chuang, LY Chang, FJ Hsieh, LC Lai, KJ Chang, Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan, PLoS One, 11, ppe28222-0
2011 TP Lu, LC Lai, MH Tsai, PC Chen, CP Hsu, JM Lee, CK Hsiao, EY Chuang, Integrated analyses of copy number variations and gene expression in lung adenocarcinoma, PLoS One, 9, ppe24829-0
2011 FH Hsu, HI Chen, MH Tsai, LC Lai, CC Huang, SH Tu, EY Chuang, Y Chen, A model-based circular binary segmentation algorithm for the analysis of array CGH data, BMC Res Notes, 1, pp394-0
2011 SY Lin, SC Hsieh, YC Lin, CN Lee, MH Tsai, LC Lai, EY Chuang, PC Chen, CC Hung, LY Chen, WS Hsieh, DM Niu, YN Su, HN Ho, A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity, Genes Immun
2011 H Chen, TH Chen, TF Tseng, JT Lu, CC Kuo, SC Fu, WJ Lee, YF Tsai, YY Huang, EY Chuang, YJ Hwang, CK Sun, High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model, Opt Express, 22, pp21552-62
2011 Pei-Chun Chen, Yen-Ching Chen, Liang-Chuan Lai, Mong-Hsun Tsai, Shin-Kuang Chen, Pei-Wen Yang, Yung-Chie Lee, Chuhsing K. Hsiao, Jang-Ming Lee, and EY Chuang, The Use Of Germline Polymorphisms In Predicting Concurrent Chemoradiotherapy Response In Esophageal Cancer, Int. J. Radiation Oncology Biol. Phys
2011 LC Lai, YY Su, KC Chen, MH Tsai, YP Sher, TP Lu, CY Lee, and EY Chuang, Down-Regulation of NDRG1 Promotes Migration of Cancer Cells during Reoxygenation, PLoS One, 8, ppe24375-0
2011 Hsien-Chi kuo, Po-Yu Lin, Ting-Chiun Chung, Chin-Mei Chao, Liang-Chuan Lai, Mong-Hsun Tsai, and Eric Y. Chuang, Database of CpG islands and analytical tools for identifying comprehensive Methylation profiles in cancer cells, Journal of Computational Biology, 8, pp1013-1017
2010 Tzu-Pin Lu, Liang-Chuan Lai, Be-i Lin, Li-Han Chen, Tzuhung Hsiao, Howard L. Liber, John A. Cook, James B. Mitchell, Mong-Hsun Tsai , Eric Y. Chuang, DISTINCT SIGNALING PATHWAYS AFTER HIGHER OR LOWER DOSES OF RADIATION IN THREE CLOSELY RELATED HUMAN LYMPHOBLAST CELL LINES, Int. J. Radiation Oncology Biol. Phys, 1, pp212-219
2010 Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, Shih JY, Yang PC, Hsiao CK, Lai LC, and Chuang EY, Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women, Cancer Epidemiol Biomarkers Prev, pp2590-2597
2010 Hsiao TH, Lin CH, Lee TT, Cheng JY, Wei PK, Chuang EY, and Peck K*, Verifying expressed transcript variants by detecting and assembling stretches of consecutive exons, Nucleic Acids Res., 38:e187.
2010 Lu TP, Lai LC, Lin BI, Chen LH, Hsiao TH, Liber HL, Cook JA, Mitchell JB, Tsai MH, and Chuang EY., Distinct signaling pathways after higher or lower doses of radiation in three closely related human lymphoblast cell lines, Int J Radiat Oncol Biol Phys.,76, 212-219. (SCI), pp212-219
2009 Lin YF, Nagasawa H, Peng Y, Chuang EY, Bedford JS, Comparison of several radiation effects in human MCF10A mammary epithelial cells cultured as 2D monolayers or 3D acinar stuctures in matrigel, Radiat Res., pp708-715
2008 1. Zhanjun Guo, Mong-Hsun Tsai, Yih-Horng Shiao, Li-Han Chen, Mei-Ling Wei, Xing Lv, David Gius, John B. Little, James B. Mitchell, Eric Y. Chuang., DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation., J Biomed Sci, pp163-168
2008 Chen HI, Hsu FH, Jiang Y, et al., A probe-density-based analysis method for array CGH data: simulation, normalization and centralization, Bioinformatics, pp1749-56
2007 20. David Gius, Margo C. Funk, Eric Y. Chuang, Sheng Feng, Phyllis C. Huettner, Loan Nguyen, C. Matthew Bradbury, Mark Mishra, Shuping Gao, Barbara M. Buttin, David E. Cohn, Matthew A. Powell, Neil S. Horowitz, Bradford P. Whitcomb and Janet S. Rader., Profiling Microdissected Epithelium and Stroma to ModelGenomic Signatures for Cervical Carcinogenesis Accommodating for Covariates., Cancer Res., pp7113-7123
2007 19. Zhanjun Guo, Mong-Hsun Tsai, Yih-Horng Shiao, Li-Han Chen, Mei-Ling Wei, Xing Lv, David Gius, John B. Little, James B. Mitchell, Eric Y. Chuang., DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation., J Biomed Sci
2007 Y.F. Lin, C.Y. Chen, M.H. Tsai, M.S. Wu, Y.C. Wang, E.Y. Chuang, J.T. Lin, P.C. Yang, L.P. Chow, Duodenal ulcer-related antigens from Helicobacter pylori: immunoproteome and protein microarray approaches, Mol Cell Proteomics, ppnil-nil
2007 M.-H. Tsai, J.A. Cook, G.V.R. Chandramouli, W. DeGraff, H. Yan, S. Zhao, C.N. Coleman, J.B. Mitchell, E.Y. Chuang, Gene Expression Profiling of Breast, Prostate, and Glioma Cells Following Single Versus Fractionated Doses of Radiation, Cancer Res., ppnil-nil
2006 M.-H. Tsai, X. Chen, G. V. R. Chandramouli, Y. Chen, H. Yan, S. Zhao, P. Keng, H. L. Liber, C. N. Coleman, J. B. Mitchell, and E. Y. Chuang, Transcriptional Responses to Ionizing Radiation Reveal that p53R2 Protects Against Radiation-induced Mutagenesis in Human Lymphoblastoid Cells, Oncogene, pp622-32
2006 E. Y. Chuang, X. Chen, M.-H. Tsai, H. Yan, C.-Y. Li, J. B. Mitchell, H. Nagasawa, P. F. Wilson, Y. Peng, J. S. Bedford, and J. B. Little, Abnormal Gene Expression Profiles in Unaffected Parents of Patients with Hereditary Type Retinoblastoma, Cancer Res., pp3428-33
2006 W. Zhao*, E.Y. Chuang*, M. Mishra, R. Awwad, K. Bisht, L. Sun, P. Nguyen, J.D. Pennington, T.J. Wang, C.M. Bradbury, L. Huang, Z. Chen, G. Bar-Sela, M.E. Robbins, D. Gius, Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression, Clin Cancer Res, pp3823-3830
2006 J. A. Cook, E. Y. Chuang, M. H. Tsai, D. Coffin, W. Degraff, A. L. Sowers, and J. B. Mitchell, Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo, Antioxid Redox Signal, pp1263-72
2005 A. M. Samuni, U. Kasid, E. Y. Chuang, S. Suy, W. DeGraff, M. C. Krishna, A. Russo, J. B. Mitchell., Effects of Hypoxia on Radiation-Responsive Stress-Activated Protein Kinase, p53, and Caspase 3 Signals in TK6 Human Lymphoblastoid Cells., Cancer Res, pp579-586
2005 M.-H. Tsai, H. Yan, G. V. R. Chandramouli, S. Zhao, D. Coffin, C. N. Coleman, J. B. Mitchell, and E. Y. Chuang., Evaluation of Hybridization Conditions for Spotted Oligonucleotide Based DNA Microarrays., Mol. Biotechnol., pp221-224
2005 M.-H. Tsai, X. Chen, G. V. R. Chandramouli, Y. Chen, H. Yan, S. Zhao, P. Keng, H. L. Liber, C. N. Coleman, J. B. Mitchell, and E. Y. Chuang., Transcriptional Responses to Ionizing Radiation Reveal that p53R2 Protects Against Radiation-induced Mutagenesis, Submitted, ppnil-nil
2005 K. K. Tsai, E. Y. Chuang, J. B. Little, and Z.-M. Yuan, Cellular Mechanisms for Low-Dose Radiation-Induced Perturbation of the Breast Tissue Microenvironment, Cancer Res., pp6734-6744
2004 H. Ge, Y. E. Chuang, S. Zhao, M. Tong, M.-H. Tsai, J. J. Temenak A. L. Richards and W.-M. Ching, Comparative Genomics of Rickettsia prowazekii Madrid E and Breinl Strains., J. Bacteriol., pp556-565
2004 E. M. Goley, S. J. Anderson, C. Menard, E. Chuang, X. Lu, P. J. Tofilon, and K. Camphausen, Microarray Analysis in Clinical Oncology: Pre-Clinical Optimization Using Needle Core Biopsies from Xenograft Tumors., BMC Cancer, pp0.180555555555556-nil
2004 X. Lu, W. E. Burgan, M. A. Cerra, E. Y. Chuang, M.-H. Tsai, P. J. Tofilon, and K. Camphausen, Transcriptional Signature of Flavopiridol-induced Tumor Cell Death., Mol. Cancer Ther., pp861-872
2004 A. Rosenwald, E. Y. Chuang, R. E. Davis, A. Wiestner, A. A. Alizadeh, D. C. Arthur, J. B. Mitchell, G. E. Marti, D. H. Fowler, W. H. Wilson, and L. M. Staudt, Fludarabine Treatment of Chronic Lymphocytic Leukemia Patients Induces a p53-Dependent Gene Expression Response, Blood, pp1428-1434
2004 L. E. Dodd, E. L. Korn, L. M. McShane, G. V. Chandramouli, E. Y. Chuang, Correction Log Ratios for Signal Saturation in cDNA Microarrays., Bioinformatics, pp2685-2693
2004 A. Loercher, T. L. Lee, J. L. Ricker, A. Howard, J. Geoghegen, Z. Chen, J. Sunwoo, E. Y. Chuang, J. B. Mitchell, A. S. Baldwin, Jr., and C. Van Waes., Nuclear factor-kB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma, Cancer Res, pp6511-6523
2004 D. Gius, H. Cui, C. M. Bradbury, J. Cook, D. K. Smart, S. Zhao, L. Young, S. A. Brandenburg, Y. Hu, K. S. Bisht, A. S. Ho, D. Mattson, L. Sun, P. J. Munson, E. Y. Chuang, J. B. Mitchell, A. P. Feinberg., Distinct Effects on Gene Expression of Chemical and Genetic Manipulation of the Cancer Epigenome Revealed by a Multimodality Approach., Cancer Cell, pp361-371
2004 M. Lu, J. Suen, C. Frias, R. Pfeiffer, M.-H. Tsai, E. Chuang, and S. L. Zeichner., Dissection of the Kaposi’s Sarcoma-associated Herpesvirus GeneExpression Program Using the Viral DNA Replication Inhibitor Cidofovir, J. Virol., pp13637-13652
2003 A. M. Samuni*, E. Y. Chuang*, M. C. Krishna, W. Stein, W. DeGraff, A. Russo, J. B. Mitchell, Semiquinone Radical Intermediate in Catecholic Estrogen-Mediated Cytotoxicity and Mutagenesis: Chemoprevention Strategies with Antioxidants, PNAS, pp5390-5395
2003 H. Ge, Y. E. Chuang, S. Zhao, J. J. Temenak and W. Ching, Genomic Studies of Rickettsia Prowazekii Virulent vs. Avirulent Strains., Ann. NY Acad. Sci, pp671-677
2003 H. Su, N. Hu, J. Shih, Y. Hu, Q.-H. Wang, E. Y. Chuang, M. J. Roth, C. Wang, A. M. Goldstein, T. Ding, S. M. Dawsey, C. Giffen, M. R. Emmert-Buck, P. R. Taylor, Gene Expression Analysis of Esophageal Squamous Cell Carcinoma Reveals Consistent Molecular Profiles Related to a Family History of Upper Gastrointestinal Cancer, Cancer Res, pp3872-3876
2002 Y. E. Chuang, Y. Chen, C. V. Gadisetti, J. Cook, D. Coffin, M. Tsai, W. DeGraff, H. Yan, S. Zhao, A. Russo, E. T. Liu and J. B. Mitchell, Gene Expression After Treatment with Hydrogen Peroxide, Menadione, or t-Butyl Hydroperoxide in Breast Cancer Cells, Cancer Res., pp6246-6254
1999 Y. E. Chuang, Qi Chen and H. L. Liber, Radiation-induced mutations at the autosomal thymidine kinase locus are not elevated in p53-null cells., Cancer Res., pp3073-3076
1998 Y. Chuang, Q. Chen and H.L. Liber, The construction of a p53-null cell line from human lymphoblast cells for mutagenesis studies, Environ. Mol. Mutagen., ppnil-nil
1997 Y. Chuang and H.L. Liber, Mutational spectra at the thymidine kinase locus of spontaneously-arising and mitomycin C (MMC)-induced mutants in two closely related human lymphoblast cell lines., Environ. Mol. Mutagen, ppnil-nil
1996 Y. Chuang, W.C. Chen and H.L. Liber, A DNA cross-linking agent (MMC) induces systematic differences in toxicity and mutagenicity in two closely related human lymphoblast cell lines., Environ. Mol. Mutagen, ppnil-nil
1996 Y. Chuang and H.L. Liber, Effects of cell cycle position on ionizing radiation mutagenesis. I. Quantitative assays of two genetic loci in a human lymphoblastoid cell line., Radiat., pp494-500
1992 S. Liu, B. Ogretman, Y. Chuang and B. C. Stark, Selection and characterization of alpha-amylase-overproducing recombinant Escherichia coli containing the bacterial hemoglobin gene., Appl. Microbiol. Biotechnol., pp239-242