【演講】11/16(四) 12:15 Genetics of Alzheimer’s Disease
講者 : 王立三 副教授
Department of Pathology and Laboratory Medicine, University of Pennsylvania
講題 : Genetics of Alzheimer’s Disease
時間 : 2017/11/16 (四) 中午12:15-13:15
地點 : 公衛大樓 R215
Alzheimer’s disease is the most common form of dementia, affecting 5 million Americans and costing the country $259 billion a year. Characterized by extensive brain atrophy, the disease leads gradual loss of memory, speech, and executive functions over up to ten years until the patient becomes incapacitated and completely dependent upon caregivers. Despite a century of research, there is no effective means to treat or manage this disease, in part because we do not understand its cause. AD is highly heritable, and deciphering the genetic landscape of the disease may lead to new insight into the cellular processes that lead to neurodegeneration and novel targets for drug discovery.
In this talk I will introduce two initiatives for Alzheimer’s disease genetics and our latest findings. The Alzheimer's Disease Genetics Consortium (ADGC) is the largest research consortium in the United States dedicated to AD genetics, and one of the four founding members of the International Genetics of Alzheimer’s Project (IGAP). ADGC and IGAP are responsible for a majority of currently known AD genetic associations, including the 2013 Lambert et al. Nature Genetics paper reporting 20 common genetic associations with late onset AD using 74,000 subjects. The latest study (Sims et al., Nature Genetics 2017) by ADGC and IGAP reported 4 rare genetic variants (including two from two new genes) for AD with 86,000 subjects. The Alzheimer's Disease Sequencing Project (ADSP) is among the largest genome sequencing projects in the world. The project is in its third phase and will sequence up to 15,000 additional whole genomes from different populations. I will present our latest findings, challenges and our solutions in data generation and analysis, and available resources from these projects.